Liquid Levodopa/Carbidopa: Old Solution, Forgotten Complication
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منابع مشابه
Simultaneous kinetic-spectrofluorometric determination of levodopa and carbidopa using partial least-squares regression.
A simple and sensitive methodology for the simultaneous determination of levodopa and carbidopa in pharmaceutical samples is described. The method combines the advantages of fluorescence with partial least-squares (PLS) analysis, and requires no previous separation steps. The developed method is based on the oxidation of levodopa and carbidopa by cerium(IV) in a sulfuric acid medium and monitor...
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BACKGROUND Severe polyneuropathy has been observed in a number of patients treated for Parkinson's disease with Levodopa/Carbidopa intestinal gel infusion. This may reflect a rare individual complication or a systematic side effect. OBJECTIVE To investigate whether peripheral nerve function differed between patients with oral treatment versus Levodopa/Carbidopa intestinal gel infusion. METH...
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The study was conducted with the purpose to method develop and validate a Ultra Performance Liquid Chromatography method UV detector to determine Levodopa, Carbidopa and Entacapone content in table preparation using MeOH : Acetonitrile : phosphate buffer (pH 2.8, 30:40:30 v/v/v). Column is BEH C18 (2.1 x 100 mm, 5 μm), flow rate 0.3 ml per minute and run time is 4 minutes. The method was valida...
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BACKGROUND Primary writing tremor is a task-specific phenomenon that has been described as variants of essential tremor or dystonia. PHENOMENOLOGY SHOWN We describe the case of a 63-year-old female who initially had primary writing tremor, later developed Parkinson's disease, and once initiated on carbidopa/levodopa had improvement in her parkinsonism and her writing tremor. EDUCATIONAL VAL...
متن کاملLevodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle.
We hypothesized that levodopa with carbidopa, a common therapy for patients with Parkinson's disease, might contribute to the high prevalence of insulin resistance reported in patients with Parkinson's disease. We examined the effects of levodopa-carbidopa on glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in skeletal muscle, the predominant insulin-...
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